![]() ![]() Gene editing allows scientists - and could soon permit clinicians - to make changes to targeted regions in the genome, potentially ‘correcting’ genes that cause disease. This year could see the first authorization of a therapy based on CRISPR–Cas9 gene editing, that involves tweaking the DNA in the body’s non-reproductive (somatic) cells. Seventy years from now, the world might look back on 2023 as a landmark, as well. The result is a flourishing understanding of the genetic causes of diseases - and a host of therapies designed to treat them. In the 70 years since those famous words were published, researchers have poured huge effort into unravelling those features and harnessing them for medicine. “This structure has novel features which are of considerable biological interest.” “We wish to suggest a structure for the salt of deoxyribose nucleic acid (D.N.A.),” wrote James Watson and Francis Crick in this journal in 1953 ( J. ![]() ![]() A gene-editing therapy to correct deformed red blood cells in sickle-cell disease is in the works - but at what cost? Credit: Eric Grave/SPL ![]()
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